Lucia di Luciano (b. 1933, Syracuse) attended the Academy of Fine Arts and was a member of the L'Associazione Artistica Internazionale in Rome. She had her first solo exhibition in 1965 at the Numero Gallery in Rome.

Di Luciano and Pizzo met in 1956 at the Academy of Fine Arts in Rome and were married in 1959. Together they were a part of Gruppo 63 in Rome (1963). which included another artistic couple - Lia Drei and Francesco Guerrieri. The group was characterized by artistic research based on logical and mathematical principles that ultimately aimed to unite art, architecture and industrial design. The group exhibited together in Rome, Florence and Livorno, and ceased operations in September 1963. Immediately afterwards, di Luciano and Pizzo founded the group Operativo R (1963-1968), which included Franco di Vito and Carlo Carchietti. The group creates a pronounced rigidity by following the precise theoretical principles of the scientific-logical field. Lucia di Luciano and Giovanni Pizzo were part of the programmed art movement (Arte programmata). Some of the most prominent art critics of the time, such as Giulio Carlo, wrote Argan, Umbro Appolonio, Lea Vergine, Palma Bucarelli, Giancarlo Politi and others about their work. 

Lucia di Luciano and Giovanni Pizzo participated in the New Tendency 3 ​exhibition in Zagreb in 1965.